Applications

Potential Molecules for the RaniPill^™Capsule

Octreotide

Octreotide can lower levels of excess growth hormone for the treatment of acromegaly, a disorder characterized by enlargement of face, hands and feet. It can also treat diarrhea associated with certain types of tumors. The Rani platform could eliminate injections for these patients and replace them with a daily pill.

Rani has demonstrated bioavailability equivalent to subcutaneous injections in pre-clinical studies. Octreotide, our internal program, will be the first molecule to be tested in humans.

Potential Molecules for the RaniPill^™Capsule

Basal Insulin

Basal insulin or “background insulin” is used in diabetes management as a way to regulate glucose levels in between meals.  The RaniPill^™ could change the lives of millions of diabetes patients by radically reducing the amount and frequency of injections.

Potential Molecules for the RaniPill^™Capsule

GLP-1 Analog

Glucagon-like peptide-1 agonists or GLP-1 mimetics are a class of drugs used in the treatment of Type II diabetes and obesity. Available GLP-1 agonists include exenatide, liraglutide and lixisenatide. Currently, patients must administer a daily or weekly injection. The Rani platform could transform this therapy with daily pills.

Rani has demonstrated bioavailability equivalent to subcutaneous injections in pre-clinical studies.

Potential Molecules for the RaniPill^™Capsule

Parathyroid Hormone (PTH)

Commonly used for the treatment of osteoporosis, PTH increases the concentration of calcium in the blood by acting upon the parathyroid hormone 1 receptor and the parathyroid hormone 2 receptor.  A Rani product could transform this therapy replacing painful, daily injections with daily pills.

Rani has demonstrated bioavailability equivalent to subcutaneous injections in pre-clinical studies.

Potential Molecules for the RaniPill^™Capsule

Human Growth Hormone (HGH)

Human Growth Hormone (HGH) is a peptide hormone that stimulates growth, cell reproduction and regeneration, and is used in the treatment of growth disorders and growth deficiency. A Rani product could transform this therapy replacing painful weekly or daily injections with daily pills.

Potential Molecules for the RaniPill^™Capsule

Human Interferon    beta-1a

Human Interferon beta -1a is a cytokine or small protein in the interferon family used for the treatment of multiple sclerosis. Although not a cure, it is believed that interferons may slow the progress of multiple sclerosis if started early and continued for the duration of the disease. Current therapy includes painful weekly intramuscular injections or subcutaneous injections 3x/week. The Rani platform could transform this therapy with daily pills.

Potential Molecules for the RaniPill^™Capsule

TNF-alpha (TNFα) Inhibitors

TNF-alpha (TNFα) inhibitors suppresses response to tumor necrosis factor, part of the inflammatory response. TNFα Inhibitors are used to treat a number of inflammatory disorders including rheumatoid arthritis and Crohn’s disease. A Rani product could transform this therapy replacing painful, biweekly injections with a daily pill.

Rani has demonstrated bioavailability equivalent to subcutaneous injections in pre-clinical studies.

Potential Molecules for the RaniPill^™Capsule

Interleukin Antibodies

There are a number of therapeutic antibodies targeting a number of interleukins including IL-6, IL-13, IL-17, IL-22 and IL-23 that are gaining acceptance as treatments for various inflammatory diseases, such rheumatoid arthritis, Crohn’s disease and psoriasis, among others. While these have their own profile including individual performance and side effects, these interleukin antibodies each has a potential role to play in treating specific autoimmune and inflammatory diseases.   

Potential Molecules for the RaniPill^™Capsule

PCSK9

A treatment for cardiovascular disease, PCSK9 is often used in combination with other therapies like statins to lower low-density lipoprotein cholesterol (LDL-C) for patients with hyperlipidemia. Because many of these patients already use statins, they are accustomed to oral therapies.  The RaniPill^TM would offer a more patient-friendly solution than the current PCSK9 injections. 

Potential Molecules for the RaniPill^™Capsule

Factor VIII, Factor IX, Factor X

Factor VIII, IX and X are used for the treatments of blood clotting disorders including Hemophilia A and B.  The RaniPill™ could be used for routine prophylaxis to reduce the frequency of bleeding episodes and perioperative management of bleeding.